___________ diseases are often due to over-functioning or under-functioning internal glands or organs.

___________ diseases are often due to over-functioning or under-functioning internal glands or organs.

• A. Digestive
• B. Muscular
• C. Skin
• D. Systemic

Answer: (D)

The main idea is that systemic diseases involve the whole body because they stem from dysfunction of internal glands or organs that regulate hormones and other widespread processes. When a gland overproduces or underproduces its hormones, those signals travel through the bloodstream and affect multiple organs and systems, leading to a broad, body-wide impact rather than a localized issue. This is why diseases linked to hormonal or endocrine imbalance are described as systemic. For example, overactive thyroid speeds up metabolism and can affect heart, nerves, and energy levels; diabetes from pancreatic hormone imbalance affects circulation, kidneys, nerves, and more. In contrast, digestive, muscular, or skin conditions are typically more localized to a specific tissue or organ and don’t inherently describe widespread hormonal dysfunction across the body.

The main idea is that systemic diseases involve the whole body because they stem from dysfunction of internal glands or organs that regulate hormones and other widespread processes. When a gland overproduces or underproduces its hormones, those signals travel through the bloodstream and affect multiple organs and systems, leading to a broad, body-wide impact rather than a localized issue. This is why diseases linked to hormonal or endocrine imbalance are described as systemic. For example, overactive thyroid speeds up metabolism and can affect heart, nerves, and energy levels; diabetes from pancreatic hormone imbalance affects circulation, kidneys, nerves, and more. In contrast, digestive, muscular, or skin conditions are typically more localized to a specific tissue or organ and don’t inherently describe widespread hormonal dysfunction across the body.